How to Treat Lung Cancer with Bone Metastasis?

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  1. Make a protective barrier between bones and osteoclasts (specialized cells that can break down bones).
  2. Affect the formation of osteoclasts.
  3. Making some changes to the signals between osteoclasts and osteoblasts (specialized cells to help make new bones), so thus this may help restore the balance of both specialized cells.
  4. And if necessary, bisphosphonates may be able to make osteoclasts die early.

Important points to remember:

  1. Take bisphosphonates as well as prescribed!
  2. The medicines are usually suggested to be taken with empty stomach so thus the body can absorb them more optimally. You may find it easier to take them in the morning, wait about an hour before eating anything.
  3. Drink more water to protect your kidneys when taking them. Ask your doctor about how much fluid you need to drink each day!
  4. They may interfere with your fertility. If you have a plan for pregnancy, you may need to delay taking them, discuss with your doctor for more advice!
  5. Watch out on the medical interaction! They can interfere with other medications such as antibiotics and NSAIDs.
  6. They carry some side effects. These may include the risk of lower calcium level in the blood, flu & fever like symptoms, bowel movement changes, weakness /tiredness, or irritation of esophagus. These can vary from patient to patient. If you experience one /some of these side effects, talk to your doctor!


It is a kind of monoclonal antibody (biological therapy). It is also familiar known by its brand names, ‘Prolia’ and ‘Xgeva’.

Prolia is commonly used to help prevent spinal fractures. For such case, typically it is prescribed for men with weakened bones due to another cancer treatment (especially such as hormone therapy for prostate cancer).

Xgeva is approved for the treatment of bone fractures or other bone problems related to cancer that has spread to the bones. Sometime, it is also prescribed to control and reduce bone damage due to a non-cancerous growth in the bone (such as giant cell tumor of the bone).

How does it work? It can target RANKL, a protein that controls the activity of osteoclasts. Therefore, it can reduce the activity of osteoclasts in breaking down the bone.

Like other cancer treatments, it carries some side effects, too. These include difficulty breathing and diarrhea. It may also cause pain of muscle, joint, or bone! The side effects can vary from patient to patient. And they may get better or worse during the course of the treatment.

What else?


Furthermore, the treatment for lung cancer with bone metastasis is also dependent on the symptoms that you have!

For instances:

  1. Additional treatment such as pain killers may be prescribed to help ease the pain.
  2. Platelet or blood transfusions can be used if patient have low levels of blood cells.

Another treatment to help strengthen bone may be with cementoplasty. It uses special cement inserted into the bones to fill parts that have been destroyed by cancer.

Sometime steroid may also be one of treatment options when cancer causes extra pressure on the spinal cord. For more detailed information about the treatment options for secondary bone cancer, discuss with your doctor!

Citations /references:



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